Other possible causes of Alzheimer's disease

 Blood vessels Previously, scientists believed the damage to blood vessels that occurs in Alzheimer's disease was responsible for brain death. But existing evidence suggests that high blood pressure also increases the risk of Alzheimer's disease. The link between blood vessel damage caused by high blood pressure and the build-up of beta-amyloid may be bidirectional, because beta-amyloid plaques damage blood vessels, so damaged blood vessels also block beta-amyloid clearance.

Metal ion oxidative stress is a series of adaptive reactions caused by the imbalance between active oxygen components and resistant oxygen system, which can produce harmful substances such as peroxide and free radicals. As we age, the mitochondria, the energy factories in our cells, gradually get out of whack, eventually leading to oxidative stress. This, in turn, damages neurons, which in turn impairs cognitive performance. And, more importantly, if you can't correct mitochondrial, recycling "sick" has been used by these mitochondria of metal ions (copper, iron, etc.) may eventually appear in the wrong place, leading to loss neurons and synapses, or the hippocampus and cerebral cortex atrophy, so patients with symptoms such as memory loss, cognitive and behavioral defects.

Prions Prions are misfolded proteins that can cause more damage by inducing other proteins of the same type to misfold. Some people think Alzheimer's is a prion disease. Both forms of beta amyloid and tau appear to have prion-like activity in the brains of alzheimer's patients who have died. If prion-like forms of these proteins are a driver of the disease, treatments targeting those specific forms would be more effective.

Insulin resistance Some studies have suggested that people with type 2 diabetes are more likely to develop Alzheimer's disease and other forms of dementia, but the mechanism is unclear. Insulin seems to be important for synapses to form and maintain normal functioning. Insulin levels also affect the function of blood vessels, which are essential for supplying blood to the brain.