On December 8, my country's first new coronavirus neutralizing antibody combination therapy drug with independent intellectual property rights was approved. The approved combination drug (ampavirimab and romisvirimab) has saved more time for treatment. Compared with other new crown treatment drugs in the world, the combination drug gives a golden treatment period of up to 10 days. The final results of the phase III clinical trial showed that whether the patient went to outpatient treatment 1 to 5 days (early stage) after the onset of symptoms, or started receiving treatment 6 to 10 days (late stage), the hospitalization and mortality rates were significantly reduced. This provides a longer treatment window for patients with new crowns.
"Neutralizing antibody drug development is to find antibodies from the immune system of the infected person that can neutralize the virus and block it from entering the cell." Zhang Linqi, the head of the research and development team and a professor at Tsinghua University School of Medicine, said in a previous interview that the team is not only focusing on the antibody itself. , Also study their "family tree", for example, what are the similarities and differences between the antibodies of the two "sisters" relationship, through micro-level comparison, we can judge the relationship between antibody structure and antiviral activity, and find antibodies with better clinical efficacy.
"Compared with the new coronavirus antibody drugs that have been approved for emergency use in Europe and the United States, we are the only one that has evaluated the therapeutic effect of patients infected with variant strains and obtained data." Zhang Linqi said.
In order to prolong the efficacy of the drug, the research team has also undergone genetic modification to extend the half-life of the drug so that it can be effective in the body for several months. In addition, the application of bioengineering technology greatly reduces the risk of antibody-mediated dependence enhancement.
"These unique characteristics mean that the combination medication is not only effective in treating patients with new crown infection, but also effective in preventing high-risk groups or people with immunodeficiency who are not infected." Zhang Linqi said that research and analysis related to preventive effects are ongoing. middle.
There is a highly praised poem on the Internet-"Walking in My Time Zone". In terms of time, New York is three hours ahead of California, but California has not slowed down. Someone graduated at the age of 22, but waited five years to find a good job! Some people became CEOs at the age of 25, but died at the age of 50. Some people did not become CEOs until they were 50 and eventually lived to be 90 years old.
Everyone in the world has their own development time zone. Some people around you seem to be walking in front of you, while others seem to be walking behind you. But in fact, everyone has their own pace in their own time zone. Don't be jealous or laugh at them. Life is waiting for the right time to act, so relax, you are neither behind nor leading. Everything is very punctual in your own time zone arranged for you by fate.
A friend who grows green pepper told me: The seeds of green pepper are more peculiar than ordinary crops. After sowing, the time of germination varies, sooner or later, the difference may be more than a year. Therefore, when planting green pepper, you must be patient. What's the use of being anxious, every seed has its own rhythm. Life never refuses to be uniform, they are not in a hurry, brewing the sunshine, wind and rain in their time zone. In the time zone of life, fast and slow, running and still, are very punctual.
In winter, in the mountains of the Jinsha River at the junction of Sichuan and Yunnan, the warm sunshine pours unreservedly from the open blue sky. However, many trees remained indifferent, maintaining a dry posture. Under such warm sunshine, how did those trees know that spring has not yet come? They dormant quietly, dormant under the brown bark. The locals smiled and answered my question: They have their own rhythm, which is a secret we cannot know. There is more latent in life than manifestation.
Life has its own time zone. It is not a standard and neat product on the assembly line. It requires efficient planning and design. They have their own four seasons. Time is not only used to catch up, but also to brew and ferment, and to grow calm and peaceful aura in silence.
